Methylation Signal Test · Buccal-Swab Kit

A non-invasive
cheek
swab,
read as
methylation data for
physician interpretation.

The AXIONOVA Methylation Signal Test is an informational tool that generates data for use within physician-governed clinical protocols. You collect a cheek sample at home, activate it with a scan, and send it back. ALETHA reads your methylation signal and presents it in AXIONOVA BIO for practitioner review.

Sample Type
Buccal Swab
Collection
At-Home
Activation
QR Kit Bind
Results
AXIONOVA BIO
Governance
ALETHRA
Posture
Physician-Directed
AXIONOVA™ Methylation Signal Test KitKit Render
Sample
Buccal Swab
At-home cheek-cell capture, no needles, no clinic visit.
Activation
QR Kit Bind
Each kit is bound to your consent and identity at activation.
Your Data
Governed by ALETHRA
Only you and the practitioners you authorize can see your signal.
Interpretation
ALETHA + Practitioner
Delivered in AXIONOVA BIO under human-in-the-loop review.
What the Test Reveals

Your DNA, read
as one connected
signal.

The kit captures DNA from your cheek cells and reads its methylation patterns, the chemical marks that tune how your genes behave. ALETHA reads these together as one connected pattern rather than a list of isolated results, so what reaches AXIONOVA BIO is a picture a practitioner can actually interpret.

Why We Test

We measure first,
then match the compound
to your biology.

Methylation is one of the body’s master control layers. It governs how you process folate and B12, clear homocysteine, and switch genes on and off. A single common variant can quietly change what your body needs, so the population-standard dose is rarely yours. We read the signal first, so your protocol is matched to your biology instead of averaged across everyone.

A control layer

It sits upstream of a lot: detoxification, how your cells repair, and which genes stay switched on or off. Small shifts here ripple outward into energy, mood, inflammation, and how you age.

One variant changes your needs

A common variant like MTHFR C677T can lower how efficiently you methylate. The dose that fits the average person is often not the dose your body can actually use.

Measured, not guessed

Reading your signal lets ALETHA match the exact nutrient and compound to your biology, instead of averaging across a population and hoping it lands.

One signal, worked through
Your signalMTHFR C677T
What it meansMethylation runs lean, homocysteine trends up
Your compoundMethylated-B stack, target homocysteine below 8

See it matched to a full profile in the sample report below.

How It Works

The action is simple.
The chain of custody is governed.

Swab your cheek at home and scan the kit’s QR code. That scan binds the sample to your consent and identity, so it stays yours end to end. Drop it in the prepaid mailer. AXIONOVA tracks it through processing, and a licensed practitioner reviews your signal in AXIONOVA BIO.

What You Receive

Your signal, read
as a protocol you
can explore.

You don’t get a raw data dump. ALETHA connects your methylation signal and genetic variants to the biomarkers that matter, then to a lean, physician-directed set of recommendations. Below is an illustrative sample, built on a fictional persona, so you can see what a reviewed protocol looks like before you begin.

Illustrative sample built on a fictional persona. Not a real subject and not medical advice. Prescription required.

Integrated genetic analysis

Sample DNA

Elena MarchettiAge 33FSample MXDEDCBG2865Analysis 2025-04-24
~3.2 billionbase pairs
  • High cognitive ability
  • High mental agility
  • Average neuroticism
  • Good stress resilience
  • Efficient dopamine metabolism
Key genes: COMT · BDNF · MTR
  • High likelihood of being a sprinter
  • Average muscle endurance
  • Medium risk of muscle damage
  • High thermogenesis response to cold
  • Average height tendency
Key genes: AMPD1 · ACTN3 · ADRB2 · MSTN
  • Lower systemic inflammation tendency
  • High lymphocyte, neutrophil and monocyte counts
  • Lower CRP levels
  • Lower resistance to malaria
Key genes: LTA · IL6 · DARC · HLA
  • Efficient carbohydrate metabolism
  • Slight tendency to overeat
  • High preference for sweets
  • Lactose intolerance high probability
  • Vitamin C low · Omega-3 low
Key genes: FTO · MCM6 · LCT · SLC23A1
  • Average epigenetic aging
  • Average telomere length
  • Efficient DNA methylation capacity
  • High SHBG levels
Key genes: MTR · MTRR · TERT · FOXO3
  • Lower estradiol levels
  • Early menarche tendency
  • Average risk of early menopause
  • High SHBG levels
  • Complete female hormonal profile analyzed
Key genes: ESR1 · FSHB · SHBG · CYP19A1
COMTVal158Met · 2 copiesCOMTVal158Met · 2 copiesEfficient dopamine metabolism
MTHFRC677T · 1 copyMTHFRC677T · 1 copyMethylation capacity to support
ACTN3R577X · 2 copies (RR)ACTN3R577X · 2 copies (RR)Sprint and power muscle profile
APOEε3 / ε4APOEε3 / ε4Lipid metabolism to monitor
ACEI/D (ID)ACEI/D (ID)Balanced endurance and power
IL6-174G>C (GC)IL6-174G>C (GC)Lower inflammation tendency
BDNFVal66Met (Met carrier)BDNFVal66Met (Met carrier)Neuroplasticity and learning
FTOrs9939609 (TT)FTOrs9939609 (TT)Metabolism and appetite signal
VDRTaqI (TT)VDRTaqI (TT)Responsive to vitamin D
m.5178C>AADNmtm.5178C>AADNmtMitochondrial longevity marker
COMT
Val158Met · 2 copiesEfficient dopamine metabolism
MTHFR
C677T · 1 copyMethylation capacity to support
ACTN3
R577X · 2 copies (RR)Sprint and power muscle profile
APOE
ε3 / ε4Lipid metabolism to monitor
ACE
I/D (ID)Balanced endurance and power
IL6
-174G>C (GC)Lower inflammation tendency
BDNF
Val66Met (Met carrier)Neuroplasticity and learning
FTO
rs9939609 (TT)Metabolism and appetite signal
VDR
TaqI (TT)Responsive to vitamin D
m.5178C>A
ADNmtMitochondrial longevity marker
Predisposition overview
InflammationLow
Cardiovascular healthFavorable
Metabolic efficiencyHigh
Muscle performanceHigh
Cognitive performanceHigh
Longevity potentialFavorable
Europe35.5%
Central Europe · Iberian Peninsula · Eastern Europe · Sardinia
America35.1%
Native American (C & S) · Native American (North)
Western Asia8.9%
Egyptian, Levantine & Arabic
East Asia2.5%
Chinese Dai & Indochinese
Maternal lineage
Maternal Haplogroup
A
Neanderthal DNA
DNA Neanderthal
2%
  • High cognitive ability
  • High mental agility
  • Efficient dopamine and methylation metabolism
  • High thermogenic response and athletic potential
  • Lower inflammation tendency
  • Longevity favorable genetic profile
  • Vitamin C levels (low)
  • Omega-3 levels (low)
  • Tendency to overeat and sweet preference
  • Muscle damage (initial phase) medium risk
  • Lower estradiol levels
Analysis quality
High confidence
Multi-omic integration: genomics, metabolomics and clinical biomarkers
Key recommendations
Nutrition

Optimize vitamin C and omega-3 intake. Prioritize anti-inflammatory whole foods.

Training

Focus on speed and power training. Include recovery protocols for muscle regeneration.

Sleep & stress

7 to 9 hours of sleep. Daily stress management: meditation, breathwork, nature exposure.

Supplements

Omega-3, vitamin D3, magnesium, NAC, CoQ10, probiotics, collagen, vitamin C.

Biomarker monitoring

Monitor inflammation, lipids, hormones, and micronutrients regularly to adjust your protocol.

Restore today. Built tomorrow. Evolve forever.
Who It’s For

Registered participants
in governed research
pathways.

Access is registration-gated. Participants start inside the AXIONOVA system, and ALETHRA confirms consent, identity, and permissions before a kit ships. The signal informs a practitioner’s review; it does not direct dosing or guarantee outcomes.

Prescription Required. Compounded medications are prepared for individual patient use pursuant to a valid prescription from a licensed practitioner. Compounded medications are not FDA-approved. All clinical decisions, including dosing, are made by your licensed physician. AXIONOVA does not practice medicine.

Begin With the Biological Signal

Request access to
the Methylation Signal Test.

Start the buccal-swab pathway. Once access is authorized, collect your sample at home, activate it with a scan, and ALETHA delivers your methylation signal in AXIONOVA BIO once processing is complete.